Meroterpenoid MAPKAP (MK2) Inhibitors Isolated from the Indonesian Marine Sponge Acanthodendrilla sp.

Journal of Natural Products
2004.0

Abstract

(+)-Makassaric acid (1) and (+)-subersic acid (2), new meroterpenoid inhibitors of the protein kinase MK2, have been isolated from the marine sponge Acanthodendrilla sp. collected in Indonesia. The structures of (+)-makassaric acid (1) and (+)-subersic acid (2) were determined by spectroscopic analysis.

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