A new potent antifungal agent from Actinoplanes sp

Tetrahedron Letters
1998.0

Abstract

A novel antifungal agent, Sch 56036 (1), was isolated from the fermentation culture broth of an Actinoplanes sp. Structure elucidation of 1 was accomplished by the analysis of spectroscopic data. Compound 1 was identified as a new polycyclic xanthone. Biological evaluation of 1 indicated that the compound possesses broad spectrum antifungal activity against various yeasts and dermatophytes with geometric mean MIC values ranging from 0.017--0.031 gg/mL, respectively.

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