Polycyclic Macrolactams Generated via Intramolecular Diels–Alder Reactions from an Antarctic Streptomyces Species

Organic Letters
2019.0

Abstract

Three new polycyclic macrolactams, cyclamenols B-D (1-3), together with a known macrolactam, cyclamenol A (4), were isolated from the Streptomyces sp. OUCMDZ-4348. Their structures including absolute configurations were determined on the basis of spectroscopic analysis, chemical methods, and ECD calculations. The biosynthetic pathways involving intramolecular Diels-Alder reactions were proposed. Compound 1 exhibited selective inhibition against the gastric carcinoma cell line N87 with an IC

Knowledge Graph

Similar Paper

Polycyclic Macrolactams Generated via Intramolecular Diels–Alder Reactions from an Antarctic <i>Streptomyces</i> Species
Organic Letters 2019.0
Polycyclic Macrolactams Generated via Intramolecular Diels–Alder Reactions from an Antarctic <i>Streptomyces</i> Species
Organic Letters 2019.0
Niizalactams A–C, Multicyclic Macrolactams Isolated from Combined Culture of <i>Streptomyces</i> with Mycolic Acid-Containing Bacterium
Journal of Natural Products 2015.0
Niizalactams A–C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium
Journal of Natural Products 2015.0
New polycyclic tetramate macrolactams from marine-derived Streptomyces sp. SCSIO 40060
Tetrahedron 2018.0
Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams
Marine Drugs 2019.0
Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams
Marine Drugs 2019.0
Absolute Configuration and Antibiotic Activity of Piceamycin
Journal of Natural Products 2020.0
Heronamides A–C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electrocyclization
Organic &amp; Biomolecular Chemistry 2010.0
Heronamides A–C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electrocyclization
Organic &amp; Biomolecular Chemistry 2010.0