Biosynthesis of the indolizidine alkaloid, cyclizidine

Journal of the Chemical Society, Chemical Communications
1987.0

Abstract

The 1H and 13C n.m.r. spectra of cyclizidine (1) have been completely assigned and incorporation experiments with 13C-labelled sodium acetate and propionate and sodium [3- 2H3]propionate have revealed that the entire carbon skeleton of (1) is derived from these precusors by a polyketide-type biosynthetic pathway, with the cyclopropyl ring being derived from a single propionate unit.

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