Topsentin C (7), dragmacidon A (8) and dragmacidon B (9), three new brominated bis(indole) alkaloids, have been isolated from the Pacific Ocean sponge Hexadella sp. collected off the coast of British Columbia. The proposed structures for 7, 8 and 9 are based on spectroscopic analysis. Dragmacidon A (8) showed significant cytotoxicity in the L1210 assay. © 1990.