<jats:p> A new hetisine-type alkaloid, named as guan-fu base A<jats:sub>1</jats:sub> (1), and five known alkaloids including guan-fu base G (2), guan-fu base Y (3), guan-fu base Z (4), guan-fu base Q (5) and coldephnine (6) were isolated from the roots of Aconitum coreanum. The structure of 1 was established by spectral methods, especially 2D NMR techniques.