<jats:title>Abstract</jats:title><jats:p>During the sequencing of the gene <jats:italic>GSP2</jats:italic> from <jats:italic>Saccharomyces cerevisiae</jats:italic>, we have encountered an adjacent open reading frame having strong homology to the 3‐phosphoserine aminotransferase (E.C.2.6.1.52) from other organisms. In this report, we present the sequence for this yeast <jats:italic>SERC</jats:italic>, and evidence that its deletion from the yeast genome leads to serine dependency. The sequence has been deposited in the GenBank data library under Accession Number L20917.