The novel derivative 1α-hydroxy-6β-propionyloxy-9-oxo-10αH-furanoeremophilane was isolated from Senecio hualtaranensis together with two known furanoeremophilanes and two pyrrolizidine alkaloids. From the closely related species S. fabrisii the same alkaloids were obtained, but in this case sesquiterpenes were not isolated. The phytochemical analysis of another three species of the Senecio genus is also reported.