Bisebromoamide, a Potent Cytotoxic Peptide from the Marine Cyanobacterium Lyngbya sp.: Isolation, Stereostructure, and Biological Activity

Organic Letters
2009.0

Abstract

A novel cytotoxic peptide, termed bisebromoamide (1), has been isolated from the marine cyanobacterium Lyngbya sp. Its planar structure was determined by 1D and 2D NMR spectroscopy. The absolute stereostructure of 1 was determined by chemical degradation followed by chiral HPLC analysis. Bisebromoamide (1) exhibited potent protein kinase inhibition: the phosphorylation of ERK in NRK cells by PDGF-stimulation was selectively inhibited by treatment with 10-0.1 microM of 1.

Knowledge Graph

Similar Paper

Bisebromoamide, a Potent Cytotoxic Peptide from the Marine Cyanobacterium <i>Lyngbya</i> sp.: Isolation, Stereostructure, and Biological Activity
Organic Letters 2009.0
Revised structure and structure–activity relationship of bisebromoamide and structure of norbisebromoamide from the marine cyanobacterium Lyngbya sp.
Tetrahedron 2011.0
Lyngbyacyclamides A and B, novel cytotoxic peptides from marine cyanobacteria Lyngbya sp.
Tetrahedron Letters 2010.0
Lyngbyaureidamides A and B, two anabaenopeptins from the cultured freshwater cyanobacterium Lyngbya sp. (SAG 36.91)
Phytochemistry 2012.0
Isolation and Structure of the Cytotoxin Lyngbyabellin B and Absolute Configuration of Lyngbyapeptin A from the Marine Cyanobacterium <i>Lyngbya m</i><i>ajuscula</i>
Journal of Natural Products 2000.0
Isolation and Structure of the Cytotoxin Lyngbyabellin B and Absolute Configuration of Lyngbyapeptin A from the Marine Cyanobacterium <i>Lyngbya m</i><i>ajuscula</i>
Journal of Natural Products 2000.0
Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides
Tetrahedron 2012.0
Lyngbyaureidamides A and B, two anabaenopeptins from the cultured freshwater cyanobacterium Lyngbya sp. (SAG 36.91)
Phytochemistry 2012.0
Isolation and Structure Determination of Obyanamide, a Novel Cytotoxic Cyclic Depsipeptide from the Marine Cyanobacterium <i>Lyngbya confervoides</i>
Journal of Natural Products 2002.0
Isolation and Structure Determination of Obyanamide, a Novel Cytotoxic Cyclic Depsipeptide from the Marine Cyanobacterium <i>Lyngbya confervoides</i>
Journal of Natural Products 2002.0