Alkaloids of Fumaria densiflora

Journal of Natural Products
1986.0

Abstract

As part of a research program dealing with the study of the chemical constituents of Jordanian flora, Fumaria densiflora DC. (Syn: F. micrantha Lag) was investigated for its alkaloidal content. The plant is an annual herb which is widespread in Jordan, especially in the Jordan Valley and the hilly areas parallel to that valley. Previously, eight alkaloids were isolated from F. densiflora. These were fumaramine, protopine, cryptopine, coptisine, palmatine, adlumidiceine, sinactine, and densiflorine (1-3). In the present work, fourteen known alkaloids have been isolated and identified in the plant. (+)-α-Hydrastine, fumaridine, parfumine, parfumidine, fumaritine, cheilanthifoline, (±)-scoularine, isosalutaridine, (±)-aldumidine, N-methylhydrasteine, fumariline, and (±)-bicuculline are reported for the first time from this source. The previously reported protopine and cryptopine have also been isolated from the plant. Another unidentified alkaloid has been obtained, and its structure is still under investigation.

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