Inhibition of Tumor-Promoter-Enhanced 3H-Choline Incorporation into Cellular Phospholipids by Phloroglucinol Derivatives from Mallotus japonicus

Journal of Natural Products
1991.0

Abstract

The MeOH and CHCl3 extracts of the pericarps of Mallotus japonicus showed potential anti-tumor-promoter activity. Seven constituents of the CHCl3 extract and two derivatives from the most abundant constituent, mallotojaponin, markedly inhibited the incorporation of 3H-choline into phospholipids of C3H101/2 cells enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter.

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