Five new bioactive metabolites, theopederins F-J, have been isolated from the marine sponge, Theonella swinhoei. Their structures are derivatives of theopederins on the basis of spectral data. Theopederin F was antifungal against Saccharomyces cerevisiae at 1 µg/disk and cytotoxic against P388 murine leukemia cells with an IC50 value of 0.15 ng/mL.