<jats:title>Abstract</jats:title><jats:p>Five new hybrid peptide–polyketides, curvularides A–E (<jats:bold>1</jats:bold>–<jats:bold>5</jats:bold>), were isolated from the endophytic fungus <jats:italic>Curvularia geniculata</jats:italic>, which was obtained from the limbs of <jats:italic>Catunaregam tomentosa</jats:italic>. Structure elucidation for curvularides A–E (<jats:bold>1</jats:bold>–<jats:bold>5</jats:bold>) was accomplished by analysis of spectroscopic data, as well as by single‐crystal X‐ray crystallography. Curvularide B (<jats:bold>2</jats:bold>) exhibited antifungal activity against <jats:italic>Candida albicans</jats:italic>, and it also showed synergistic activity with a fluconazole drug.