L-755,807, A new non-peptide bradykinin binding inhibitor from an endophytic Microsphaeropsis sp.

Tetrahedron
1996.0

Abstract

A new metabolite, L-755,807,1, was isolated from an endophytic Microsphaeropsis sp. in the course of searching for a bradykinin binding inhibitor. The structure of 1, including relative stereochemistry, was determined. 1 showed an ICso of 71 PM in 3H-bradykinin binding to a cloned human B2 receptor.

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