Pyripyropenes, Novel ACAT Inhibitors Produced by Aspergillus fumigatus. IV. Structure Elucidation of Pyripyropenes M to R.

The Journal of Antibiotics
1996.0

Abstract

Six new pyripyropenes, M to R, were isolated from the ethyl acetate extracts of the jar fermentation broth of Aspergillus fumigatus FO-1289-2501. Structural elucidation indicated that all the pyripyropenes have the same pyridino-alpha-pyrone sesquiterpene core as pyripyropenes A to L. Among them pyripyropene M showed the most potent inhibition against acyl-CoA : cholesterol acyltransferase activity with an IC50 value of 3.80 microM in rat liver microsomes, but pyripyropenes N to R showed moderate inhibitory activity (IC50 11.0 approximately 78.0 microM).

Knowledge Graph

Similar Paper

Pyripyropenes, Novel ACAT Inhibitors Produced by Aspergillus fumigatus. IV. Structure Elucidation of Pyripyropenes M to R.
The Journal of Antibiotics 1996.0
Pyripyropenes, Novel ACAT Inhibitors Produced by Aspergillus fumigatus. III. Structure Elucidation of Pyripyropenes E to L.
The Journal of Antibiotics 1995.0
Pyripyropenes, highly potent inhibitiors of ACYL-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus.
The Journal of Antibiotics 1993.0
Pyripyropenes, novel inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D.
The Journal of Antibiotics 1994.0
GERI-BP001 Compounds, New Inhibitors of Acyl-CoA: Cholesterol Acyltransferase from Aspergillus fumigatus F37. I. Production, Isolation, and Physico-chemical and Biological Properties.
The Journal of Antibiotics 1995.0
GERI-BP001, a new inhibitor of acyl-CoA: Cholesterol acyltransferase produced by Aspergillus fumigatus F37
Tetrahedron Letters 1994.0
AS-186 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase from Pencillium asperosporum KY1635.
The Journal of Antibiotics 1994.0
Isochromophilones III -VI, Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216.
The Journal of Antibiotics 1995.0
Lateritin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Gibberella lateritium IFO 7188.
The Journal of Antibiotics 1993.0
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 2
Bioorganic & Medicinal Chemistry Letters 2013.0