New Steroidal Alkaloids from Rhizomes of Veratrum album

Journal of Natural Products
1992.0

Abstract

The EtOH extract of the rhizomes of Veratrum album has afforded two new alkaloids, (+)-jervinone [1] and (+)-verabenzoamine [2]. The structures 1 and 2 were determined by spectral analysis (¹H and ¹³C nmr, DEFT, 2D COSY, and NOESY). Veratrum species have been noted for their pharmacological activity for well over 300 years. Until about 1950 the extracts of Veratrum species were mainly used as insecticides. The alkaloids from Veratrum have also found use in the treatment of hypertension (1,2). Since 1930 Veratrum species have been studied chemically, yielding over 100 alkaloids, some of which have been pharmacologically evaluated (3-6). We have recently restudied Veratrum album L. (Liliaceae) and obtained several new alkaloids (7). We report here the isolation and structure elucidation of two new alkaloids, the jerveratrum-type (+)-jervinone [1] and cevane-type (+)-verabenzoamine [2].

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