Nine East Malaysian liverworts have been investigated chemically. Frullania serrata produces eudesmane-, germacrane-, eremophilane and elemane-type sesquiterpenoids and bibenzyls and is classified as chemotype I of the Frullaniaceae. Wiesnerella denudata elaborates not only germacranolides but also cyclic bis(bibenzyls), marchantins A and B. The major components of Trichocolea pluma is prenyl 3,4-dimethoxybenzoates, the chemical markers of the Trichocoleaceae. Mastigophora species are chemically almost identical to those of Herbertus because both genera produce unique isocuparene-type sesquiterpenoids and isocuparene dimers. Chandonathus, Heteroscyphus, Lepidozia, Scapania and Schistochila species produce various types of sesquiterpenoids which have been widely distributed in the other liverworts.