Gypsophin: A novel α-glucosidase inhibitory cyclic peptide from the roots of Gypsophila oldhamiana

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

An unusual new cyclic peptide with a pyrrolidine-2,5-dione unit, gypsophin (1), was isolated from Gypsophila oldhamiana. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was determined by application of the Marfey's method and the single-crystal X-ray diffraction. Compound 1 exhibited inhibitory activity against alpha-glucosidase with IC50 of 305 microM.

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