Phenylpropanoid-Conjugated Triterpenoids from the Leaves of Actinidia arguta and Their Inhibitory Activity on α-Glucosidase

Journal of Natural Products
2020.0

Abstract

<i>Actinidia arguta</i>, commonly called hardy kiwifruit or kiwiberry, has cold-resistant properties and can be cultivated in Asia, including Korea. Seven new triterpenoids (<b>2</b>-<b>4</b> and <b>8</b>-<b>11</b>) along with eight known triterpenoids were isolated from the leaves of <i>A. arguta</i> through various chromatographic techniques. The new triterpenoids were defined as actiniargupenes A-C (<b>2</b>-<b>4</b>), actinidic acid derivatives with phenylpropanoid constituent units, dehydroisoactinidic acid (<b>8</b>), and actiniargupenes D-F (<b>9</b>-<b>11</b>), asiatic acid derivatives with phenylpropanoid substituents, on the basis of 1D and 2D NMR and MS data. Among the triterpenoids, those with a phenylpropanoid constituent unit showed inhibitory activity on α-glucosidase, which suggested the importance of the phenylpropanoid moiety. Molecular docking analysis demonstrated the interaction between the 4'-OH group of the phenylpropanoid moiety and α-glucosidase.

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