Four new metabolites, 4-<i>epi</i>-citreoviridin (<b>1</b>), auransterol (<b>3</b>), and two analogues (<b>2</b> and <b>4</b>) of paxisterol (<b>6</b>), together with two known metabolites (15<i>R</i>*,20<i>S</i>*)-dihydroxyepisterol (<b>5</b>) and (<b>6</b>), were isolated from cultures of the fungal associate, <i>Penicillium aurantiacobrunneum</i>, of the lichen <i>Niebla homalea</i>, endemic to California and Baja California. The structures of all compounds were determined by comprehensive spectroscopic and spectrometric methods, as well as single-crystal X-ray diffraction for the determination of the absolute configuration of <b>3</b>. Compound <b>1</b> showed selective cytotoxicity toward MCF-7 breast and A2780 ovarian cells with IC<sub>50</sub> values of 4.2 and 5.7 μM, respectively.