Two new 7,8-dihydro-8-oxoprotoberberine alkaloids, cerasodine (1) and cerasonine (2), were isolated from the stem bark of Polyalthia cerasoides (Annonaceae). Polyalthia cerasoides (Roxb.) Bedd. (Annonaceae) is a medium-sized tree occurring mainly in Asiatic and Oceanic areas.1 In a previous study on P. cerasoides several prenylated benzopyran derivatives were isolated.2-4 We discuss here the isolation and structure elucidation of two new oxoprotoberberine alkaloids, cerasodine (1) and cerasonine (2), from the EtOAc extract of P. cerasoides stem bark. Previous phytochemical studies on Polyalthia species had led to the isolation of several tetrahydroprotoberberine alkaloids,5-8 some of which presented an ortho-diphenolic substitution on ring D, and exhibited cytotoxic, antioxidant, and dopaminergic activity.9-11