The leaves and bark of Guatteria goudotiana were investigated for their alkaloid content. From the leaves, 15 alkaloids were isolated: the 1-benzylisoquinolines, (+)-reticuline and (-)-juziphine; the morphinandienone, (-)-pallidine; the noraporphines, (-)-3-hydroxynornuciferine, (+)-laurotetanine and (+)-norisodomesticine; the aporphines, (+)-neolitsine, (+)-isodomesticine, (+)-N-methyllaurotetanine, (+)-isoboldine and (+)-corytuberine; the dehydroaporphines, dehydroneolitsine, dehydronantenine and goudotianine; and the oxoaporphine, liriodenine. From the bark, the following four alkaloids were isolated: the noraporphines, (+)-norisodomesticine and (-)-anolobine; the dehydroaporphine, goudotianine; and the phenanthrene alkaloid, argentinine. This is the first time the dehydroaporphines, dehydroneolitsine and goudotianine, have been isolated from a natural source. © 1991.