Ansamycin Antibiotics as Free Radical Scavengers Isolated fromStreptomycesby Using the Bactericidal Action of the Hydroxyl Radical

Bioscience, Biotechnology, and Biochemistry
1996.0

Abstract

Ansamycin antibiotics (1-4) were isolated from the cultured broth of Streptomyces sp. USF-319 strain as a result of our screening for free radical scavengers. They inhibited the bactericidal effect of the Fenton reagent toward Bacillus subtilis by their radical scavenging activity. Some of them also showed inhibitory activity against lipid peroxidation and lipoxygenases.

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