A Novel Antimycin-like Compound, JBIR-06, from Streptomyces sp. ML55

The Journal of Antibiotics
2008.0

Abstract

A novel compound of antimycin family, JBIR-06 (1), was isolated from Streptomyces sp. ML55. The structure of 1 was established as a twelve-membered macrocyclic skeleton with a 3-(formylamino)-2-hydroxybenzamide based on the spectroscopic data. Compound 1 inhibited the expression of GRP78 induced by 2-deoxyglucose at the IC50 value of 250 nM.

DOI： 10.1038/JA.2008.35

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