A new C22N2 Lycopodium alkaloid, senepodine F (1), consisting of a decahydroquinoline and a quinolizidine ring has been isolated together with senepodines A (2) and E (3) from the club moss Lycopodium chinense. The relative stereochemistry of 1 was determined by NOESY correlations for a deacetylated derivative. © 2004 The Japan Institute of Heterocyclic Chemistry All rights reserved.