A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first hybrid dimer found in the Ancistrocladaceae; rr! vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum. Published by Elsevier Science Ltd.