Total Synthesis of Covalent Cysteine Protease Inhibitor N-Desmethyl Thalassospiramide C and Crystallographic Evidence for Its Mode of Action

Total Synthesis of Covalent Cysteine Protease Inhibitor <i>N</i>-Desmethyl Thalassospiramide C and Crystallographic Evidence for Its Mode of Action Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure–Activity Relationship and Binding Mode Analysis Biosynthetic Multitasking Facilitates Thalassospiramide Structural Diversity in Marine Bacteria Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A Cystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp. Total synthesis of grassystatin A, a probe for cathepsin E function Synthesis and disulfide bond connectivity–activity studies of a kalata B1-inspired cyclopeptide against dengue NS2B–NS3 protease Design, synthesis and biological evaluation of peptidyl-vinylaminophosphonates as novel cysteine protease inhibitors