<jats:title>Abstract</jats:title> <jats:p> Besides the already reported alkaloids [1-5] from the root bark extract of Discaria febrifuga Martius, two further peptide alkaloids, the known discarine-B and discarine-I are isolated and their structures elucidated. Discarine-I is a fourteen-m em bered ring peptide alkaloid and the ring is constituted by p-hydroxy styrylamine, β-hydroxyleucine, N-methylisoleucine and tryptophan