Three Tyrosinase Inhibitors and Antioxidant Compounds from Salsola foetida

Abstract

<jats:title>Abstract</jats:title><jats:p>Phytochemical investigation on the whole plant of <jats:italic>Salsola foetida</jats:italic> resulted in the isolation of three new phenolic compounds <jats:bold>1, 2</jats:bold>, and <jats:bold>3</jats:bold>, which exhibit tyrosinase inhibition with moderate antioxidant activity. Compounds <jats:bold>1</jats:bold>–<jats:bold>3</jats:bold> inhibited tyrosinase with <jats:italic>IC</jats:italic><jats:sub>50</jats:sub> 2.61, 1.85, and 0.40 μ<jats:sc>M</jats:sc>, while exhibiting DPPH radical scavenging activity with <jats:italic>IC</jats:italic><jats:sub>50</jats:sub> 383, 427 and 378 μ<jats:sc>M</jats:sc>, respectively. The structures of <jats:bold>1, 2</jats:bold>, and <jats:bold>3</jats:bold> were determined by modern spectroscopic techniques.