A new alkaloid isorhazicine (2) has been isolated from the leaves of Rhazya stricta. The structure and relative stereochemistry have been determined by spectroscopic studies, particularly by NOE difference, COSY-45 ° and DEPT experiments. Isorhazicine (2) was shown to differ from rhazicine (1) in that it bears a 'Z' configuration of the ethylidene group. © 1987.