(Chemical Equation Presented) Mussel power: The structures and configurations have been determined of four new indole alkaloids, notoamides A-D, which were isolated from mussel-derived Aspergillus sp. Notoamides A-C show moderate cytotoxicity against cancer cell lines. The relationship between these and other metabolites suggests that the fungus uses a diverse biosynthetic pathway. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.