The indole derivatives 1-3 were isolated from the fruit bodies of Tricholoma sciodes and T. virgatum, and their structures were determined by spectroscopy. The compounds are new natural products, although 2,4-dimethylindole (1) previously has been prepared synthetically. Despite their wide occurrence in Nature, species belonging to the genus Tricholoma (Basidiomycetes) have been poorly studied in respect to their contents of secondary metabolites. In the course of our respective screening programs of European Basidiomycetes we have investigated the fruit bodies of T. sciodes Mart. and T. virgatum Kummer, two species that both are considered inedible because of their bitter and acrid taste. TIC analyses of ethyl acetate extracts revealed the presence of several compounds that were not present in other Tricholoma species investigated recently. Silica gel column and centrifugal radial chromatography afforded the three indole derivatives 1-3 shown in Figure 1. The structure determination of the compounds was based on high resolution mass spectroscopy data, which suggested the elemental composition of the compounds, and on the NMR data which are summarized in Table 1 (1H NMR and 13C NMR data), as well as in Figure 2 [1H-13C long-range and NOESY correlations for 4-methoxymethyl-2-methylindole (3)]. The indoles reported here are new as natural products, although 2,4-dimethylindole (1) has been prepared synthetically. However, the spectroscopic data given previously are insufficient for an identification, and a full set of data is therefore given here.