The Isolation and Structural Elucidation of Three New Neolignans, Puberulins A, B, and C, as Platelet Activating Factor Receptor Antagonists for Piper puberulum

Journal of Natural Products
1995.0

Abstract

Three new neolignans, piperulins [corrected] A [1], B [2], and C [3], were isolated from Piper puberulum. Their structures and relative stereochemistries were determined from spectral data and the X-ray crystallographic analysis of 1. Compounds 1 and 3 inhibit specific platelet activating factor receptor binding with IC50 values of 7.3 and 5.7 microM, respectively.

Knowledge Graph

Similar Paper