A new alkaloid, hiautine, was isolated from Corcdus hirsrctus. Its structure has been assigned as 1 on the basis of chemical and spectral studies. Plants of the Indian subcontinent are a continuing source of fascinating natural products. Cocculus hirsutus (L.) Diels (Menispermaceae), locally known as "jamti-ki-bel," is a climbing shrub commonly found in southeastern Pakistan. Its various parts are known for their medicinal properties in the indigenous systems of medicine (1-3). Earlier investigations of various parts of this plant led to the isolation of trilobine, coclaurine, magnoflorine, and sitosterol (4-6). As a result of continuing investigations, we have isolated hirsutine, a new isoquinoline alkaloid, to which structure 1 has been assigned on the basis of chemical and spectral studies.