Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family

Discovery of Cryptic Largimycins in <i>Streptomyces</i> Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family Discovery of the leinamycin family of natural products by mining actinobacterial genomes Leinamycin, a new antitumor antibiotic from Streptomyces; Producing organism, fermentation and isolation. Leinamycin, a new antitumor antibiotic from Streptomyces; Producing organism, fermentation and isolation. Identification and Localization of the Gene Cluster Encoding Biosynthesis of the Antitumor Macrolactam Leinamycin in <i>Streptomyces atroolivaceus</i> S-140 Leinamycin Biosynthesis Revealing Unprecedented Architectural Complexity for a Hybrid Polyketide Synthase and Nonribosomal Peptide Synthetase Synthesis and evaluation of 8,4′-dideshydroxy-leinamycin revealing new insights into the structure–activity relationship of the anticancer natural product leinamycin Synthesis and characterization of a small analogue of the anticancer natural product leinamycin Juanlimycins A and B, Ansamycin Macrodilactams from <i>Streptomyces</i> sp. Juanlimycins A and B, Ansamycin Macrodilactams from <i>Streptomyces</i> sp.