Structure elucidation of secondary metabolites isolated from the leaves of Ixora undulate and their inhibitory activity toward advanced glycation end-products formation

Phytochemistry
2014.0

Abstract

Three aromatic glycosides (1-3), two sulfur and nitrogen-containing compound glucosides (4, 5), and one flavonoid glycoside (6) were isolated from the leaves of Ixora undulata. Their structures were established by extensive 1D, 2D NMR, and HRESIMS experiments, and structure 4 was further confirmed by single crystal X-ray diffraction analysis. Of the assayed compounds, 7, 11 and 12 showed strong inhibitory activity toward advanced glycation end-products formation with IC50 values of 86.0 μM, 76.6 μM and 98.6 μM, respectively.

Knowledge Graph

Similar Paper

Structure elucidation of secondary metabolites isolated from the leaves of Ixora undulate and their inhibitory activity toward advanced glycation end-products formation
Phytochemistry 2014.0
Structure elucidation of secondary metabolites isolated from the leaves of Ixora undulate and their inhibitory activity toward advanced glycation end-products formation
Phytochemistry 2014.0
α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of <i>Desmos cochinchinensis</i>
Journal of Natural Products 2019.0
Phloroglucinol Benzophenones and Xanthones from the Leaves of <i>Garcinia cowa</i> and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities
Journal of Natural Products 2020.0
Flavan-3-ols Having a .GAMMA.-Lactam from the Roots of Actinidia arguta Inhibit the Formation of Advanced Glycation End Products in Vitro
Chemical and Pharmaceutical Bulletin 2009.0
Inhibitors of Aldose Reductase and Formation of Advanced Glycation End-Products in Moutan Cortex (<i>Paeonia suffruticosa</i>)
Journal of Natural Products 2009.0
α-Glucosidase Inhibitory Isomeric Corniculatolides from the Stems of the Indian Mangrove Plant, <i>Xylocarpus granatum</i>
Journal of Natural Products 2020.0
New Acylated Iridoid Glucosides from <i>Vitex </i><i>a</i><i>ltissima</i>
Journal of Natural Products 2004.0
Indole alkaloid glycosides from Isatis tinctoria roots
Natural Product Research 2021.0
Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea
Bioorganic &amp; Medicinal Chemistry Letters 2010.0