Chromatographic separation of EtOH extracts of the stems of Derris scandens has yielded six new diprenylisoflavones, named derrisisoflavones A±F, together with six known isoflavones. Their structures were elucidated by spectroscopic analyses. The known compounds were lupalbigenin, scandinone, erysenegalensein E, lupinisol A, lupinisoflavone G and 5, 7,4'trihydroxy-6, 8 diprenylisoflavone. Anti-dermatophyte activity of the isolated isoflavones from D. scandens against Trichophyton mentagrophytes was also examined.