Six nitrile glucosides and one cyanogenic glucoside (epiheterodendrin) have been isolated from the leaves of members of the Rosaceae-Prunoideae and Rosaceae-Kerrieae. Two of these, 4-fl-n-glucopyranosyloxy-2R,3R-epoxy-3-hydroxymethyl-butyronitrile (sutherlandin epoxide) and 4-fl-D-glucopyranosyloxy-3S-methyl-butyronitrile (dihydroosmaronin), are new compounds. The aglycones of all the nitrile glucosides are apparently derived from L-leucine. The distribution and taxonomic significance of these glucosides in the species investigated is discussed briefly.