<jats:title>Abstract</jats:title> <jats:p>The phytochemical study of the leaves, roots, and flowers of <jats:italic>Palicourea rigida</jats:italic> led to the isolation of the triterpenes betulinic acid (<jats:bold>1</jats:bold>) and lupeol (<jats:bold>2</jats:bold>), the diterpene phytol (<jats:bold>3</jats:bold>), and the iridoid glycosides sweroside (<jats:bold>4</jats:bold>) and secoxyloganin (<jats:bold>5</jats:bold>). These compounds were identified using NMR <jats:sup>1</jats:sup>H and <jats:sup>13</jats:sup>C and comparing the spectra with published data. We studied the antiedematogenic activity of crude extracts from the organs, and of different fractions, in mice and found that the <jats:italic>n-</jats:italic>hexane fraction of the leaf extract significantly inhibited the ear edema resulting from croton oil administration. The crude extract from leaves was not acutely toxic to the mice.