Thiotipin, a novel thiopeptide with a tipA promoter inducing activity produced by Streptomyces sp. DT31

Tetrahedron
1994.0

Abstract

Thiotipin was isolated from the mycelium of Streptomyces sp. DT31 as a tipA promoter inducing substance. Based on various NMR studies including 1H-1H COSY, HSQC, FG-HMBC, phase-sensitive 13C-decoupled HMBC (D-HMBC) and NOE, its structure was established as a thiopeptide with oxazoles, thiazoles and several modified amino acids. Minimum induction concentration of thiotipin for tipA promoter was 80 ng/ml. © 1994.

DOI： 10.1016/S0040-4020(01)85660-X

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