<jats:title>Abstract</jats:title><jats:p>Three new indole alkaloids, 11,12‐de(methylenedioxy)danuphylline (<jats:bold>1</jats:bold>), methyl (2<jats:italic>β</jats:italic>,11<jats:italic>β</jats:italic>,12<jats:italic>β</jats:italic>,19<jats:italic>α</jats:italic>)‐6,7‐didehydro‐8,21‐dioxo‐11,21‐cycloaspidospermidine‐2‐carboxylate (<jats:bold>2</jats:bold>), and (2<jats:italic>β</jats:italic>,5<jats:italic>β</jats:italic>)‐aspidofractinin‐16‐ol (<jats:bold>3</jats:bold>) were isolated from <jats:italic>Kopsia officinalis</jats:italic>, together with 16 known compounds. Their structures were determined by spectroscopic methods. The isolated known compound (−)‐12‐methoxykopsinaline displayed antimanic effects in Drosophila, with an <jats:italic>IC</jats:italic><jats:sub>50</jats:sub> value of 12.5 μg/ml.