One new furoquinoline alkaloid, leptanoine D (1) and nine known alkaloids 2-10 were isolated from Pitaviaster haplophyllus. Leptanoine D (1) contains a typically unstable vinyl ether moiety and was structurally elucidated based on 2D NMR, (+)-HR-ESI-MS, and ECD data. The structures of the known furoquinoline alkaloids leptanoine A (11) and B (12) have also been revised. Compounds 1-10 were screened against three species of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli), however they showed no activity at the highest dose tested (32 g mL-1). The compounds were also evaluated for anti-proliferative action against PC-3 and WPMY-1 cells, with 7-9 displaying weak activity at 100 μM. © 2021 CSIRO.