New derivatives of 3-methylcytisine with 9-aromatic substituents bonded to the pyridone core of the starting alkaloid through spacers of various natures, e.g., aminomethyl, amide, thio- and carboxamide, ethenyl, and ethyl, were synthesized from 9-amino- and 9-bromo-2-oxomethylcytisine. © 2023, Springer Science+Business Media, LLC, part of Springer Nature.