Four-Step Total Synthesis of (+)-Euphococcinine and (±)-Adaline

The Journal of Organic Chemistry
2021.0

Abstract

A four-step enantiospecific total synthesis of bicyclic homotropinone alkaloid euphococcinine and a racemic synthesis of adaline were reported. Key reactions in the synthesis are the diastereoselective addition of a Wittig phosphorene to the ketimines derived from Davis-Ellman sulfinamides, ring-closing metathesis, and intramolecular Michael reactions.

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