COVID-19 has become disastrous for world and spread all over. Researchers all around the globe are working to discover a drug to cure from COVID-19. RNA dependent RNA polymerase plays a key role in SARS-CoV-2 replication and thus it could be a potential target for SARS-CoV-2. This study revealed that Protopine, Allocryptopine and (+/-) 6- Acetonyldihydrochelerythrine could be potential RdRp inhibitors of SARS-CoV-2. CI - Copyright (c) 2020 Elsevier Ltd. All rights reserved.