Background: Nature has bestowed mother Earth with an array of herbals utilized as therapeutics for various human ailments since the origin of life. Bryonia laciniosa (family: Cucur-bitaceae) is one such herb, which finds its mention in various traditional systems of medicine and has attracted current researchers due to its significant therapeutic value. Objective: The current article aims to present a literature metasynthesis on Bryonia laciniosa. Methods: The authors performed scholarly searches for peer-reviewed findings on Bryonia lacin-iosa and incorporated all the data related to the phytochemical and therapeutic profile of the drug. Results: This compilation comprises of Phytochemical and Pharmacological profile of Bryonia laciniosa elaborating its traditional significance and recent researches related to its biological activ-ities. The plant exhibits its potential as an antimicrobial, anti-inflammatory, analgesic, antipyretic, anticonvulsant, anti-asthmatic, anticancer, antioxidant, antidiabetic, and aphrodisiac agent. It also displays its benefits in wound healing and ulcerative colitis. Conclusion: The presence of flavonoids, saponins, terpenoids, anthocyanins, coumarins, alkaloids, polyphenols, tannins and emodins in this plant is responsible for its various pharmacological activi-ties. The retrospective study provides direction for existing research as well as future studies to support the domain of pharmaceutical and medical sciences. © 2023 Bentham Science Publishers.