Pd-Catalyzed C–H Functionalization of Indole-Containing Alkene-Tethered Aryl Halides with Alkynes To Construct Indole Alkaloid Scaffolds

Organic Letters
2022.0

Abstract

: A convenient and straightforward approach for the construction of indole alkaloid scaffolds from indole-containing alkene-tethered aryl halides and alkynes through a sequential C-H activation, five-membered palladacycle formation, and alkyne insertion process has been described. The approach provides a series of indole alkaloid compounds in moderate to excellent yields with good functional tolerance

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