Total Synthesis of 6-Hydroxymetatacarboline-d Discovered from Mycena metata via the Pictet–Spengler Reaction Followed by the Horner–Wadsworth–Emmons Reaction

ACS Omega
2021.0

Abstract

Total synthesis of a new beta-carboline alkaloid, 6-hydroxymetatacarboline-D, which was isolated from fruiting bodies of Mycena metata was accomplished in 14 steps. The synthetic strategy features the Pictet-Spengler reaction to construct the tricyclic core followed by amide coupling and the Horner-Wadsworth-Emmons reaction.

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