Total synthesis of isatindigotindoline C

Organic & Biomolecular Chemistry
2020.0

Abstract

Total synthesis of isatindigotindoline C, a 3,3'-spiropyrrolidine oxindole alkaloid, is achieved in two steps using an exo-selective decarboxylative 1,3-dipolar cycloaddition as the key step. The synthesis verifies the originally assigned relative anti-stereochemistry for the bis-oxindole core of isatindigotindoline C.

DOI： 10.1039/d0ob00270d

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