Total syntheses of carbazole alkaloid mukoenine A and pyrano[3,2-a]carbazole alkaloid girinimbine

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2022.0

Abstract

In this study, we achieved the total synthesis of carbazole alkaloid mukoenine A through a seven-step sequence involving the construction of a carbazole framework using the electrocyclization of a 6n -electron system including an allene intermediate as the key step. Subsequently, the synthesis of pyrano [3,2-a]carbazole alkaloid girinimbine was achieved by the construction of the pyran ring via selenoe-therification of the o-allylic phenol moiety of mukoenine A. (c) 2022 Elsevier Ltd. All rights reserved.

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